Publications
Publications in peer-reviewed journals
Aksamitiene E*, Baker AL*, Roy S, Hota S, Zhang LH, Rodin J, Hobelmann K, Hoek JB, Pribitkin EA. (2017) "Biochemical Effects of Exercise on a Fasciocutaneous Flap in a Rat Model" JAMA Facial Plastic Surgery 19(4):303-310. IF: 2.703 PubMed
Roy S*, Aksamitiene E*, Hota, S, Zhang, LH, Sciarrino, J, Baker, AL, Heffelfinger RN, Tuluc M, Hoek JB, Pribitkin, EA (2016) "Aging effects on pedicled fasciocutaneous flap survival in rats" Head & Neck April 38 Suppl 1:E1152-62 IF: 3.376 PubMed
Correnti JM, Cook D, Aksamitiene E, Swarup A, Ogunnaike B, Vadigepalli R, Hoek JB. (2014) “Adiponectin fine-tuning of liver regeneration dynamics revealed through cellular network modeling”. The Journal of Physiology 593: 365-383 IF: 4.544 PubMed
Birtwistle MR, Rauch J, Kiyatkin A, Aksamitiene E, Dobrynski M, Hoek JB, Kolch W, Ogunnaike BA, Kholodenko BN. (2012) "Bimodal Cell Population Responses Can Emerge from the Interplay Between Analog Single-Cell Signaling and Protein Expression Noise" BMC Systems Biology 6:109. IF: 3.57 PubMed
Aksamitiene E, Kiyatkin A, Kholodenko B. (2012) "Crosstalk between mitogenic Ras/MAPK and survival PI3K/AKT pathways: a fine balance". Biochemical Society Transactions 40(1):139-46. IF: 3.989 PubMed
Aksamitiene E, Achanta S, Kolch W, Kholodenko BN, Hoek JB, Kiyatkin A. (2011) "Prolactin-induced activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase-dependent Rac/PAK pathway in breast cancer cells". Cellular Signalling 23(11):1794-805. IF: 4.243 PubMed
Aksamitiene E, Kholodenko BN, Kolch W, Hoek JB, Kiyatkin A. (2010) "PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells". Cellular Signalling 22: 1369–1378. IF: 4.243 PubMed
Borisov N*, Aksamitiene E*, Kiyatkin A*, Legewie S, Berkhout J, Maiwald T, Kaimachnikov N, Timmer J, Hoek J. B., Kholodenko B. N. (2009) "Systems-level interactions between insulin and epidermal growth factor networks potentiate mitogenic signaling". Molecular Systems Biology 5: 256. IF: 9.667 PubMed * - Authors contributed equally
Aksamitiene E, Hoek, J. B., Kholodenko, B. N., Kiyatkin, A. B. (2007) "Multi-strip Western blotting to increase quantitative data output". Electrophoresis 28(18): 3163-73. IF: 3.569 PubMed
Kiyatkin, A. B., Aksamitiene E, Markevich, N. I., Borisov, N. M., Hoek, J. B. & Kholodenko, B. N. (2006) "Scaffolding protein GAB1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops". Journal of Biological Chemistry 281: 19925-19938. IF: 5.328 PubMed
Book chapters
Fey D, Aksamitiene E, Kiyatkin A., Kholodenko B. N. (2017) Chapter 27. "Modeling of Receptor Tyrosine Kinase Signaling: Computational and Experimental Protocols" In: Tan AC., Huang P. (eds) Kinase Signaling Networks Methods in Molecular Biology Vol. 1636, pp. 417-453. Humana Press, New York, NY. PubMed
Aksamitiene E, Hoek JB, Kiyatkin A. (2015) Chapter 23. "Multistrip Western blotting: a tool for comparative quantitative analysis of multiple proteins" In: Kurien B., Scofield R. (eds) Western Blotting. Methods in Molecular Biology Vol. 1312, pp. 197-226. Humana Press, New York, NY. PubMed
Anatoly Kiyatkin and Edita Aksamitiene. (2009) Chapter 17. "Multistrip Western blotting to increase quantitative data output" In: Kurien B., Scofield R. (eds) Protein Blotting and Detection: Methods and Protocols. Methods in Molecular Biology Vol. 536, pp. 149-161. Humana Press, Totowa, NJ. IF: 13.9 PubMed
Manuscripts in preparation or submitted
Aksamitiene E, Mitchell-Waters C, Bryant L, Hoek JB, Pribitkin, EA Heffelfinger RN. "Detailed protocol of standardized reconstructive surgery animal model to study physiological, biochemical and molecular mechanisms of skin flap healing" for Nature’s Lab Animal.
Aksamitiene E, Bryant L, Hall MB, Eisenbrey JR, Stanczak M, Hoek JB, Forsberg F, Pribitkin EA and Heffelfinger R. "Prognostic significance of tissue oxygenation gain score estimated by combined photoacoustic and laser Doppler ultrasound imaging for pedicled epigastric fasciocutaneous advancement flap outcome in a pre-clinical rat animal model". Journal of Investigative Dermatology
Aksamitiene, E, Pribitkin EA and Heffelfinger, RN. "Molecular responses of rat skin to ischemia and reperfusion during free tissue transfer: differences and similarities to human patient flaps". The Journal of Surgical Research
Aksamitiene E, , Mitchell-Waters C, Bryant L, Park K, Pribitkin EA, Heffelfinger RN. "Pre-clinical evaluation of gender-dependent tolerance of fasciocutaneous flaps to ischemia". Wound Repair and Regeneration
Aksamitiene E, Christopher V, Mitchell-Waters C, Juskeviciute E, Addiya S, Hoek JB, Pribitkin EA and Heffelfinger RN. "Pre-clinical identification of diagnostic molecular biomarkers of secondary ischemia in fasciocutaneous epigastric flaps". Journal of Cellular and Molecular Medicine
Aksamitiene E, Ciolek P, Hjelm N, Pribitkin EA, Heffelfinger RN. "The evaluation of therapeutic and preventative efficacy of platelet-rich plasma in ischemic skin flap survival" Journal of Plastic and Reconstructive Surgery
Aksamitiene E, Kiyatkin A, Kholodenko, B, Hoek JB. "Anti-proliferative, pro-apoptotic and chemosensitizing effects of dietary flavonoid luteolin in pancreatic cancer cells" Molecular Cancer Therapeutics IF: 5.225
Aksamitiene E, Kiyatkin A, Hoek JB. "The molecular targets of alcohol" Alcoholism: Clinical and Experimental Research (review article) IF: 3.31
Patents
Aksamitiene E et al. "Multi-strip Western blotting procedure to increase quantitative data output", US provisional patent 103786 issued on 2008
Scientific Meetings and Conferences
Edita Aksamitiene, Lucas Bryant, Maria Stanczak, John R Eisenbrey, Jan B Hoek, and Edmund A Pribitkin (2016) "Prognostic significance of tissue oxygenation changes and early signaling responses in fasciocutaneous advancement flap healing". The FASEB Journal 30:444.10. Experimental Biology 2016. April 2 – April 6. San Diego, CA. Oral presentation
Edita Aksamitiene, Sudeep Roy, Kealan Hobelmann, Julianna Rodin, Giuseppe V Staltari, Edmund A Pribitkin, Joannes B Hoek. (2015) "Single-pedicled Fasciocutaneous Flap Survival In Aged Rat Model of Chronic Alcoholism". The FASEB Journal 29:889.13. Experimental Biology 2015. March 28 – April 1. Boston, MA. Poster presentation.
Aksamitiene, E, Roy S, Baker, AL, Hota S, Zhang, L, Hobelmann, K, Rodin J, Heffelfinger R, Hoek JB, Pribitkin EA. (2014) “Single-pedicled fasciocutaneous flap survival in ageing rat model of voluntary cardiovascular exercise”. ASCB/IFCB Meeting, 2014, December 6-10, Philadelphia, PA. Poster presentation. Click on the image below to download full-resolution POSTER as PDF file (47.3 Mb - may take a while to load).
Adam L. Baker MD*, Edita Aksamitiene PhD*, Salini Hota BS, Li-Hui Zhang BS, Sudeep Roy MD, Jan B. Hoek PhD, Edmund A. Pribitkin MD. (2014) "Pedicled Fasciocutaneous Flap Response to Cardiovascular Exercise in an Animal Model". 5th World Congress – IFHNOS and Annual Meeting AHNS, July 26-30, New York, NY. Poster presentation
Jan B Hoek, Edita Aksamitiene and Anatoly Kiyatkin. (2013) "Ethanol, Cell Signaling, and Gene Regulatory Networks in Cancer". 2nd Alcohol and Cancer Conference, May 11 - 13, Breckenridge, CO.
Aksamitiene E, Achanta S, Kiyatkin A, Hoek JB. (2012). "Synergistic anti-tumor effect by a combination treatment of dietary flavonoid luteolin and chemotherapy drugs Tasigna or Adrucil in human pancreatic cancer cells". The FASEB Journal 26:999.4. Experimental Biology 2012, April 21 – 25, San Diego, CA. Poster presentation Received ASBMB Graduate and Postdoctoral Travel Award. Click on the image below to download full-resolution POSTER as PDF file (11 Mb).
Aksamitiene E, Achanta S, Hoek JB, Kiyatkin A (2011). "Effects of dietary flavonoid luteolin on short-, medium- and long-term growth factor-mediated signaling in pancreatic and breast cancer cells". Cell Signaling Networks 2011, October 22 – 27, Merida, Yucatan, Mexico. Poster presentation
Kiyatkin A, Aksamitiene E, Achanta S, Kholodenko BN, Hoek JB. (2011). "Quantitative analysis of the crosstalk between growth factor-cytokine signaling networks". Gordon Research Conference on Cellular Systems Biology, July 24-29, Davidson, NC. Poster presentation
Aksamitiene E, Achanta S, Kiyatkin A, Hoek JB. (2011). "The routes of ERK activation in prolactin-stimulated breast cancer cells". The FASEB Journal 25: 946.1. Experimental Biology 2011, April 9 – 13, Washington DC. Poster presentation. Click on the image below to download full-resolution POSTER as PDF file (15 Mb).
Birtwistle M, Vyshemirsky V, Girolami M, Sturm O, Orton R, Grindlay J, Gilbert D, von Kriegsheim A, Rauch J, Kiyatkin A, Aksamitiene E, Hoek JB, Ogunnaike BA, Kholodenko BN, Kolch W. (2010). "Systems properties of ERK signaling". 11th International Conference on Systems Biology, October 10 – 16, Edinburgh, Scotland. Parallel oral session No. 8.4
Hoek JB, Juskeviciute E, Crumm S, Aksamitiene E, Kiyatkin A, Vadigepalli R, Kholodenko BN. (2010). "Synergy in cell signaling and gene expression in the context of liver regeneration". 11th International Conference on Systems Biology, October 10 – 16, Edinburgh, Scotland. Parallel oral session No. 8.4
Aksamitiene E, Antony AN, Kiyatkin A, Hoek JB. (2010). "The effects of ethanol on prolactin signaling in normal and regenerating liver hepatocytes". Molecular Biology of the Cell 21: 2661. ASCB 50th Annual Meeting, December 11 – 15, Philadelphia, PA. Poster presentation. Click on the image below to download full-resolution POSTER as PDF file (4.19 Mb).
Aksamitiene E, Kiyatkin A, Hoek JB. (2010) "Tumor cell sensitivity to growth inhibition correlates with the strength of interaction between cell survival and mitogenic signaling pathways". 5th Annual Jefferson Postdoctoral Research Symposium, June 15, Philadelphia, PA. Poster presentationn.
Aksamitiene E, Kiyatkin A, Hoek JB. (2010) "Dynamic cross-talk between PI3-kinase/Akt and Ras/ERK pathways in EGF receptor signaling that can affect drug sensitivity in tumor cells". The FASEB Journal 24: 715.2. Experimental Biology 2010, April 24-28, Anaheim CA. Poster presentation. Received ASBMB Graduate and Postdoctoral Travel Award.Click on the image below to download full-resolution POSTER as PDF file (11.2 Mb).
Aksamitiene E, Kiyatkin A, Hoek JB. (2008) "Adaptor protein GAB1 is a critical node connecting cell survival and mitogenic pathways in epidermal growth factor receptor signaling". 3rd Annual Jefferson Postdoctoral Research Symposium, June 24, Philadelphia, PA. Oral presentation. Received "The Best Presenter" award.
Aksamitiene E. (2006). "The modulation of adaptor proteins by RNA interference in signal transduction". 9th Lithuanian Biochemical Society Conference-Meeting "Biochemistry: science and knowledge society". June 16-18, Tolieja, Moletai, Lithuania. Keynote Speech - Oral presenation.